Course

Heterocyclic Chemistry

Indian Institute of Technology Kharagpur

Course outline:

Nomenclature, classification
Aromatic heterocycles
Non-aromatic heterocycles
Heterocyclic synthesis

Course topics:

Introduction
- Definition of heteroatom and alkaloids and bases
- Importance of heterocycles and heterocycles in medicine
- Nomenclature and common names
- Structure and aromaticity; Structure determination
General characteristics
- Effect of heteroatoms on organic reactions:comparison with carbogenic compounds
- Palladium in heterocyclic chemistry
- Oxidation and reductions in heterocyclic chemistry
- Tertiary amino effect
Aromatic heterocyclic chemistry
- Pyrrole group
- Pyridine group
- Indole group
- Quinoline group
- Miscellaneous group
Non-aromatic heterocyclic chemistry
- Oxirane group
- Oxetane
- Furan
- Pyran
Miscellaneous group
- Functional molecules and organocatalysts
- Heterocycles in organic synthesis
- Biomolecules
- Industrial molecules
- Problems and exercises

Course Lectures

Mod-01 Lec-01 Definition and Scope
Prof. D.R. Mal

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Mod-02 Lec-02 Single - Step Methods for IVPs
Prof. D.R. Mal

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Mod-03 Lec-03 Systematic Nomenclature
Prof. D.R. Mal

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Mod-04 Lec-04 Nomenclature (Contd.) and Important Names
Prof. D.R. Mal

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Mod-05 Lec-05 Overview of Structure Determination in Heterocyclic Chemistry
Prof. D.R. Mal

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Mod-06 Lec-06 15N NMR in Heterocyclic Chemistry
Prof. D.R. Mal

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Mod-07 Lec-07 Effects of Ring Nitrogen - A
Prof. D.R. Mal

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Mod-08 Lec-08 Effects of Ring Nitrogen - B
Prof. D.R. Mal

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Mod-09 Lec-09 Effects of Ring Nitrogen - C
Prof. D.R. Mal

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Mod-10 Lec-10 Oxidation in Heterocyclic Chemistry
Prof. D.R. Mal

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Mod-10 Lec-11 Oxidation in Heterocyclic Chemistry (Contd.)
Prof. D.R. Mal

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Mod-11 Lec-12 Reduction in Heterocyclic Chemistry
Prof. D.R. Mal

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Mod-12 Lec-13 Radicals in Heterocylic Chemistry - I
Prof. D.R. Mal

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Mod-13 Lec-14 Radicals in Heterocylic Chemistry - II
Prof. D.R. Mal

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Mod-14 Lec-15 Lithiation for 5-membered heterocycles
Prof. D.R. Mal

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Mod-14 Lec-16 Lithiation for 5-membered heterocycles (Contd.)
Prof. D.R. Mal

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Mod-15 Lec-17 Lithiation of 6-membered heterocycle and non-aromatic heterocycles
Prof. D.R. Mal

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Mod-16 Lec-18 Magnetiation and Zincation in Heterocyclic Chemistry
Prof. D.R. Mal

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Mod-17 Lec-19 Transition metal catalyzed cross coupling
Prof. D.R. Mal

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Mod-17 Lec-20 Transition metal catalyzed cross coupling (Contd.)
Prof. D.R. Mal

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Mod-18 Lec-21 Dehydrogenative (Oxidative) cross coupling
Prof. D.R. Mal

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Mod-19 Lec-22 Tert-amino effect in heterocycle synthesis
Prof. D.R. Mal

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Mod-20 Lec-23 [4 plus 2] cycloaddition in heterocyclic chemistry
Prof. D.R. Mal

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Mod-20 Lec-24 [4 plus 2] cycloaddition in heterocyclic chemistry (Contd.)
Prof. D.R. Mal

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Mod-21 Lec-25 [3 plus 2] Cycloaddition in heterocyclic chemistry
Prof. D.R. Mal

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Mod-22 Lec-26 Cycloaddition : Revisited
Prof. D.R. Mal

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Mod-23 Lec-27 [4 plus 3] Cycloaddition
Prof. D.R. Mal

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Mod-24 Lec-28 [5 plus 2] Cycloaddition
Prof. D.R. Mal

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Mod-25 Lec-29 [2 plus 2 plus 2] Cycloaddition
Prof. D.R. Mal

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Mod-26 Lec-30 Pyrrole Synthesis - I
Prof. D.R. Mal

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Mod-27 Lec-31 Pyrrole Synthesis - II
Prof. D.R. Mal

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Mod-28 Lec-32 Indole Synthesis - I
Prof. D.R. Mal

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Mod-29 Lec-33 Indole Synthesis - II
Prof. D.R. Mal

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Mod-30 Lec-34 Furan Synthesis
Prof. D.R. Mal

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Mod-31 Lec-35 Thiophene Synthesis
Prof. D.R. Mal

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Mod-32 Lec-36 Oxazole, Imidazole and Thiazole Synthesis
Prof. D.R. Mal

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Mod-33 Lec-37 Pyridine Synthesis
Prof. D.R. Mal

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Mod-34 Lec-38 Synthesis of Quinolines and Isoquinolines
Prof. D.R. Mal

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Mod-35 Lec-39 Bycyclic Polyheteroatomic Heterocycles
Prof. D.R. Mal

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Mod-36 Lec-40 Heterocyclic Rearrangements
Prof. D.R. Mal

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